Beam Therapeutics is seeking a Senior Director, Value, Evidence & Development Strategy to lead the global HEOR strategy for its sickle cell disease program and other pipeline programs.
Requirements
- Provide strategic input to disease prioritization, target product profiles, clinical trial protocols, clinical development plans, and regulatory submissions
- Develop, validate, and integrate patientâcentered outcomes (PROs) into protocols and analyses
- Interpret clinical trial results (including PROs and healthcare resource use) and partner with Clinical Development/Biostatistics on Statistical Analysis Plans (SAPs) and postâhoc analyses
- Lead a fitâforâpurpose RWE strategy (EHR, claims, registries, hybrid/open datasets) including natural history/registry design and governance
- Develop and operationalize external/synthetic control arm approaches (e.g., matched registry cohorts, Bayesian borrowing) for singleâarm or smallâpopulation studies typical in cell & gene therapy
- Provide operational oversight of Medical Affairs evidence generation, including vendor/CRO governance, milestone/deliverable tracking, dataâquality plans, risk management, and onâtime execution across Medical Affairsâled studies
- Elicit and integrate perspectives from patients, KOLs, policy leaders, and internal stakeholders (market access, marketing, patient advocacy) to ensure plans meet the needs of patients, HCPs, and payers
- Support Market Access on internal and external payer/policy initiatives (pricing and reimbursement, unmet medical need, regional market dynamics, evidence gaps) across the portfolio
- Support business decisions around ex-US strategy including, but not limited to, scoping ex-US opportunities, prioritizing country engagement, early scientific advice / parallel consultations with EMA and HTA bodies (e.g., HTACG/JSC)
- Anticipate payer evidence needs and budgetâimpact critiques (including preparation for ICER Reviews)
- Build and maintain economic models (costâeffectiveness, budget impact) tailored to oneâtime CGTs, addressing uncertainty/durability and caregiver burden
- Collaborate with Market Access to design innovative payment models and outcomesâbased agreements with pragmatic outcomes and tracking
- Lead the AMCP dossier and preâapproval information exchange (PIE) strategy (6â12 months preâlaunch)
- Work collaboratively with internal teams, consultants, and CROs to advance development of the portfolio
Benefits
- Generous Paid Time Off
- 401k Matching
- Retirement Plan
- Visa Sponsorship
- Four Day Work Week
- Generous Parental Leave
- Tuition Reimbursement
- Relocation Assistance
