Senior Scientist - CMC
EmpiricoMadison, Wisconsin, United States
Posted December 12, 2025
110000 - 160000 USD year
Full Time
About the Company
Empirico is a clinical-stage biotechnology company that discovers and develops siRNA medicines designed to mimic naturally-occurring genetic variants that confer beneficial effects on health and disease.
Job Description
Empirico, a clinical-stage biotechnology company, is seeking a Senior Scientist - CMC to support the synthesis, purification, and characterization of oligonucleotides and their conjugates.
Requirements
- BS in Chemistry with at least 12 years of relevant industry experience
- MS in Organic Chemistry, Biochemistry, or Chemical Engineering with at least 7 years of relevant experience
- PhD with at least 3 years of relevant experience
- Industry experience in solid-phase oligonucleotide synthesis
- Familiarity with both upstream and downstream oligonucleotide manufacturing processes
- Minimum 1 year of experience working in a cGMP environment
- Hands-on proficiency with analytical instrumentation such as NMR, LC-MS, and RP-HPLC
- Demonstrated ability in analytical and purification method development using RPIP-HPLC, AEX-HPLC, UV, MALDI, and HRMS
- Background in process development and technology transfer to CDMOs
- Working knowledge of tangential flow filtration (TFF) method development
- Experience supporting GLP studies and familiarity with regulatory expectations for IND-enabling work
- Experience with lyophilization and aseptic fill/finish operations
Benefits
- Retirement savings plan (with company match)
- Paid vacation
- Holidays
- Health benefits to include medical, prescription drug, dental and vision coverage
