Senior Principal Scientist, Peptide Therapeutics

We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team.

Requirements

• Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field.
• A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing.
• Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies.
• Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates.
• Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS).
• Computational Methods: Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations.
• Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization.
• A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization.

Benefits

• Generous Paid Time Off
• 401k Matching
• Retirement Plan
• Visa Sponsorship
• Four Day Work Week
• Generous Parental Leave
• Tuition Reimbursement
• Relocation Assistance