Senior Director, CMC Technical Operations, siRNA Therapeutics
AlectorSouth San Francisco, California, United States
Posted February 27, 2026
240000 - 270000 USD
Full Time
About the Company
Alector is a late-stage clinical biotechnology company dedicated to combating degenerative brain disorders. Focused on high-unmet needs in neurodegenerative diseases, the company develops therapies that target toxic misfolded proteins, deficient proteins, and dysfunction in immune and neuronal systems. Utilizing proprietary technologies like Alector Brain Carrier (ABC) for blood-brain barrier transport and deep expertise in drug development, Alector aims to restore normal function in affected cells.
Job Description
We are a biotech company developing therapies that empower the immune system to combat neurodegeneration. As a Senior Director, CMC Technical Operations, you will lead CMC strategy, drive development and manufacturing of siRNA therapeutics, and provide technical oversight of CDMOs.
Requirements
- BS, MS, or PhD in Chemical Engineering, Biochemistry, Pharmaceutical Sciences, or a related scientific discipline
- Significant experience in CMC development within biotechnology, with direct experience in siRNA, oligonucleotide, or other RNA-based therapeutics
- Demonstrated expertise in oligonucleotide drug substance manufacturing, including scale-up and GMP tech transfer
- Experience overseeing CDMO partnerships and external manufacturing activities in a clinical-stage setting
- Strong knowledge of global regulatory expectations for CMC documentation and phase-appropriate development strategies
- Excellent technical writing and communication skills
Benefits
- Competitive compensation
- Flexible hybrid work options
- Comprehensive and unique benefits that enhance your health and well-being
