Senior Scientist - LCMS Bioanalysis
AmgenSouth San Francisco, California, United States
Posted May 21, 2026
Full Time
About the Company
Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We helped establish the biotechnology industry, and we remain on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today. Our investment in research and development has yielded a robust pipeline that builds on our existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. Amgen is one of 30 companies comprising the Dow Jones Industrial Average®, and part of the Nasdaq-100 Index®. In 2024, Amgen was named one of the “World’s Most Innovative Companies” by Fast Company and one of “America’s Best Large Employers” by Forbes. For more information, visit Amgen.com and follow us on X, LinkedIn, Instagram, TikTok, YouTube and Threads. 🔗 Community Guidelines: https://wwwext.amgen.com/community-guidelines 🔗Global Privacy Statement Directory: www.amgen.com/dp Special Advisory: Please be cautious of scam recruitment offers claiming to be from Amgen. Such scams may come from various sources, including fake websites and/or unsolicited emails and seek to obtain personal data or payment from victims by offering jobs that do not exist. Please be advised that Amgen would never ask for payment to progress a job application. When in doubt, please check to see if the position in question is posted on this website before applying. Additionally, please report any suspicious recruiting activity to https://complaint.ic3.gov/ and thank you for your assistance.
Job Description
Join Amgen's Mission of Serving Patients. As a Senior Scientist - LCMS Bioanalysis, you will develop and apply innovative LC-MS-based bioanalytical assays to quantify therapeutic candidates, assess target engagement and modulation, characterize target dynamics, and measure biomarkers across discovery and development programs.
Requirements
- Develop, optimize, and perform quantitative LC-MS assays to measure therapeutics of all modalities (including exposure and biotransformation), biomarkers and target dynamics (including target abundance, target engagement/ occupancy, target turnover kinetics, and cellular trafficking of target).
- Design and implement bioanalytical strategies that support mechanistic understanding of drug-target interactions, pathway modulation, pharmacodynamic responses, and biomarker kinetics.
- Apply quantitative mass spectrometry-based workflows to support studies in complex biological matrices, including plasma, tissue, and in vitro systems.
- Explore, evaluate, and implement emerging analytical technologies to support novel therapeutic modalities, including complex biologics, multispecific molecules, targeted protein degradation platforms, oligonucleotide-based modalities, and other emerging therapeutic approaches.
- Independently troubleshoot assay development, sample preparation, data quality, and LC-MS instrument performance issues.
- Collaborate with cross-functional project teams to interpret bioanalytical data in the context of PK/PD, translational biomarkers, target biology, and mechanisms of action.
- Maintain accurate electronic laboratory notebook records, prepare technical reports, and communicate scientific results clearly to project teams and stakeholders.
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible
