We're seeking an experienced Process Development Engineer, Chemistry to join the Process Chemistry and Manufacturing team at Aralez Bio. This role will be a key, hands-on contributor to the process development, scale-up, and manufacturing operations for the production of a variety of non-canonical amino acids (ncAAs).
Requirements
- Execute various chemical unit operations (biocatalytic and chemical reactions, filtrations, purifications, etc.) to produce high-quality noncanonical amino acid products, in collaboration with the Production team.
- Set up, operate, monitor, maintain, and troubleshoot manufacturing equipment, including chemical reactors at various scales (10L, 100L, 1000L), filters, pumps, and other equipment and parts.
- Follow and assist in development of standard operating procedures (SOPs) and batch records to ensure accurate and consistent production.
- Maintain raw material & product inventories. Perform container change-outs for products and raw materials including chemicals and solvents.
- Perform “scale-up” and “scale-down” procedures for chemical reactions and unit operations, including optimization and troubleshooting, to ensure successful and efficient transfer from lab-scale (milligram to gram) to pilot-scale (kilogram) and eventual manufacturing scale (multi-kilogram to ton).
- Maintain quality standards by conducting in-process testing and analysis, using analytical tools such as TLC, HPLC, LCMS, and pH meter, to determine intermediate identity, purity, pH, and concentration.
- Communicate important production details (verbally and in writing). Complete appropriate documentation (e.g. batch records, log books as required), following good documentation practices.
- Participate in ongoing training to develop technical skills and enhance your understanding of chemical manufacturing processes.
- Perform preventive and corrective maintenance activities during production downtime. Clean and maintain equipment after production runs.
- Follow Safety Protocols: Adhere to safety regulations and protocols.
Benefits
- Medical / dental / vision insurance coverage
- 401k
- Flexible Spending Account
- Unlimited time off policy
- Weekly catered lunch
- Professional Development opportunities
- Annual company retreat
