The Broad Institute of MIT & Harvard is seeking a Research Scientist I to join the dynamic Methods Development Lab (MDL) to develop novel multiomic methods for ultra high-throughput single-cell sequencing technologies. The successful candidate will be responsible for the end-to-end design and execution of methods development across various technology platforms.
Requirements
- Ph.D. degree in Molecular Biology, Genetics, Bioengineering, or a related field with 2+ years of relevant, post-graduate work experience in an academic or industrial lab setting.
- Extensive, hands-on molecular biology expertise is mandatory, including proficiency in the execution of single-cell sequencing pipelines from sample collection/preparation through library construction and sequencing coordination.
- Direct experience with commercial and/or custom single-cell platforms is required. Experience with 10X Genomics, PIPseq is strongly preferred.
- Proven expertise in single-cell RNA-seq and related sequencing modalities, with a strong, demonstrable emphasis on methods development, optimization, and multiomic approaches (CITE-seq, Perturb-seq).
- Expertise in BSL2 cell culture, including the handling and processing of primary human/mouse cells and induced Pluripotent Stem Cells (iPSCs).
- Direct experience in the design, execution, and data interpretation of single-cell functional genomic perturbation screens (e.g., Perturb-seq, CRISPR-based screens) is highly preferred.
- Background in analyzing and interpreting complex sequencing data, including familiarity with relevant programming/scripting languages (R or Python) is preferred.
- Strong ability to work both independently and collaboratively. Proven experience working effectively across experimental and computational research groups in a fast-paced, matrixed environment.
- Excellent written and verbal communication skills, especially the ability to clearly and concisely describe complex experimental methods and interpret results to diverse audiences (both scientific and non-scientific).
- A publication history in peer-reviewed journals, especially those focused on novel sequencing methodologies, is strongly preferred.
Benefits
- Medical, dental, vision, life, and disability insurance
- 401(k) retirement plan
- Flexible spending and health savings accounts
- At least 13 paid holidays
- Winter closure
- Paid time off
- Parental and family care leave
- Employee assistance program
