Principal Scientist, Antibody Engineering & Rational Design

We are seeking an innovative Principal Scientist to bridge the gap between computational design and experimental validation in our antibody discovery engine.

Requirements

• Ph.D. in molecular biology, biochemistry, computational modeling, structural biology, or related discipline
• 8+ years’ post-PhD experience in antibody/protein engineering within the biotech or biopharma sectors
• Hands-on proficiency with structural modeling and extensive knowledge in ML protein design tools
• Experience designing experiments specifically to generate high-quality training data for ML models (e.g., focused libraries, systematic mutagenesis)
• Expert knowledge of antibody structure-function relationships
• Extensive experience in rational design for humanization, affinity maturation, pH-dependence, and liability removal
• Deep expertise in engineering multi-specific antibodies
• Strong understanding of biophysical characterization to ensure designed molecules are developable therapeutics
• Experience technically managing CROs for gene synthesis, protein production, and functional assays

Benefits

• Two annual cash bonuses