Senior/Principal Scientist, Chemoproteomics
CalicoSouth San Francisco, California, United States
Posted December 19, 2025
166000 - 207000 USD year
Full Time
About the Company
Calico is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging.
Job Description
Calico is seeking an experienced Scientist to join the mass spectrometry proteomics group. The work will primarily involve chemoproteomics techniques using mass spectrometry to support drug discovery.
Requirements
- PhD in Analytical Chemistry, Chemistry, Chemical Biology, Biochemistry, Chemical Engineering or related field
- Minimum 5 years technical experience post-PhD with experience in the biopharma industry
- Experience in method development for HPLC and/or mass spectrometers
- Experience in maintaining and troubleshooting HPLCs and mass spectrometers
- Experience in sample preparation for proteomics and chemoproteomics
- Experience in multiplexed proteomics (e.g. TMT)
- Experience in enrichment and analysis of PTMs
- Experience with activity based proteome profiling and cysteine enrichment workflows (e.g. CysPAT, DBIA)
- Experience in proteomics data analysis and programming (Python, R, MATLAB)
- Detail-oriented and organized
- Strong teamwork and communication skills
- A track record of strong research/drug discovery productivity
- Self-motivated with a “can-do” attitude is required for success
- Flexible, able to respond quickly to shifting priorities and able to multitask
Benefits
- Two annual cash bonuses