Centessa Pharmaceuticals is seeking a Clinical Trial Manager to lead the execution of mid- to late-stage global clinical studies. The CTM is responsible for day-to-day trial management, coordinating internal cross-functional teams and overseeing CROs and external vendors. This role requires hands-on involvement in clinical trial execution, proactive identification and resolution of operational issues, and accountability for study performance metrics and deliverable quality.
Requirements
- Plan and execute mid- to late-stage CNS clinical trials from study start-up through close-out, ensuring operational excellence, high data quality, and compliance with protocol, GCP, and global regulatory requirements.
- Lead day-to-day clinical trial operations, coordinating cross-functional partners (Clinical Development, Data Management, Biostatistics, Regulatory, Safety) to ensure efficient trial execution and alignment to program objectives.
- Oversee CROs and external vendors supporting CNS clinical trials, including co-monitoring activities, to ensure delivery against scope of work, timelines, budget, and quality expectations.
- Drive critical study milestones, including site activation, enrollment progress, patient retention, data cleaning, and database lock, proactively addressing operational challenges common to CNS trials.
- Review and approve CRO- and vendor-generated plans and study documentation, ensuring alignment with protocol, regulatory expectations, and Centessa quality standards.
- Monitor study progress and performance using operational metrics and tools, maintaining dashboards, timelines, and financial tracking, and providing clear, timely status updates to study teams and management.
- Identify, assess, and manage operational risks, proposing practical mitigation strategies and supporting informed decision-making to minimize impact to timelines, quality, and patient safety.
- Ensure inspection and audit readiness, including oversight of Trial Master File (TMF) set-up, ongoing maintenance, and close-out for CNS studies.
- Contribute to operational planning and regulatory deliverables, supporting preparation of study-level documentation for Health Authority interactions and continuous improvement of clinical operations processes.
Benefits
- 401(k) plan
- Company-sponsored medical, dental, vision, and life insurance
- Generous paid time off
- Health and wellness program
