Head of In Silico Drug Toxicity/VP of Toxicology

We are seeking a Head of In Silico Drug Toxicity to own, define, and scale our computational toxicology platform end-to-end. This role requires deep technical leadership and executive-level strategic thinking, with the ability to translate cutting-edge science into scalable, enterprise-ready systems.

Requirements

• 15+ years in computational biology, toxicology, drug discovery, or related domain
• Proven experience designing and deploying computational models for toxicity or biological systems
• Deep hands-on experience designing and deploying computational toxicology models across mechanistic, statistical, and machine learning paradigms
• Expertise in integrating ML/AI, systems biology, PK/PD modeling, and real-world data into cohesive predictive systems
• Strong track record evaluating tradeoffs between mechanistic modeling and statistical/ML approaches
• Ability to identify breakthrough opportunities beyond current industry standards
• Experience developing novel model architectures, not just QSAR or legacy approaches
• Comfortable discussing mechanistic toxicity pathways, ML architectures, regulatory strategy, and platform design
• Deep expertise in one or more of: Predictive/computational toxicology, Systems pharmacology or systems biology, Mechanistic modeling, ML/AI in drug discovery, PK/PD or ADMET modeling
• Strong understanding of preclinical safety workflows
• Familiarity with regulatory frameworks (FDA, EMA, ICH)
• Experience working with complex and proprietary pharma datasets
• Awareness of data limitations, bias, and validation challenges
• Experience leading large, interdisciplinary technical teams
• Ability to operate as both a strategic leader and a technical decision-maker
• Executive presence with senior pharma stakeholders
• Strong communication and cross-functional leadership skills
• Experience building platforms, teams, or systems from zero to scale
• Comfortable operating in ambiguity and defining direction
• Strong bias toward action, ownership, and iteration

Benefits

• Competitive compensation package with meaningful equity
• Comprehensive health, dental, and vision coverage
• Remote-friendly culture with optional onsite work
• Annual team gatherings and company events