Senior Scientist, Medicinal Chemistry
IonisCarlsbad, California, United States • Boston, Massachusetts, United States • Dublin, Ireland
Posted August 19, 2025
130476 - 160000 USD year
Full Time
About the Company
Ionis Pharmaceuticals, Inc. is a pioneer in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs.
Job Description
Ionis is seeking a motivated and innovative Senior Scientist, Medicinal Chemistry to join our team. The successful candidate will play a key role in synthesizing ligands or nucleoside monomers, incorporating them into therapeutic oligonucleotides, and performing bioconjugation of oligonucleotides to ligands targeting cell surface receptors.
Requirements
- Ph.D. in Organic or Nucleic Acid Chemistry
- At least 2 years of post-doctoral experience in academia or industry
- Experience in nucleoside/oligonucleotide synthesis and purification
- Experience with purification techniques (e.g., ion exchange, reverse-phase, and size-exclusion chromatography)
- Experience with automated lab equipment (e.g., NMR, LC-MS, etc)
- A track record of scientific productivity as evidenced by high quality publications and/or patents
- Excellent communication skills and the ability to succeed in a team environment
- An ability to be productive and successful in a fast-paced, interactive, and innovative work environment
Benefits
- Generous Paid Time Off
- 401k Matching
- Retirement Plan
- Visa Sponsorship
- Four Day Work Week
- Generous Parental Leave
- Tuition Reimbursement
- Relocation Assistance
