Principal Scientist, Analytical Development

Kymera Therapeutics is a clinical-stage biotechnology company seeking a Principal Scientist, Analytical Development to contribute to CMC activities supporting mid and late phase clinical development of small-molecule protein degraders. The role will involve executing development and validation of critical analytical methods, managing day-to-day analytical development and testing activities, and collaborating with CMC colleagues and QA to ensure analytical approaches meet global regulatory expectations and inspection readiness standards.

Requirements

• PhD in Analytical Chemistry or related life sciences field
• 7+ years of experience in CMC analytical development
• Demonstrated late phase analytical development experience in drug substance and drug product (oral solid dosage experience required)
• Experience in developing impurity control strategies, including potentially mutagenic impurities (PMIs) and nitrosamine impurities
• In-depth expertise in late phase test method development, method validation/transfer, and characterization of small-molecule drugs
• Broad analytics expertise with widely employed techniques
• Knowledgeable of compendial testing methods (USP/EP) used for DS and DP testing
• Strong working knowledge of GLP, cGMP, and ICH requirements
• Prior experience writing analytical sections in NDA/MAA filings
• Experience providing technical guidance to CDMOs and contract test labs
• Experience working cross-functionally among project teams

Benefits

• Competitive compensation package
• Market-based, performance-driven pay
• Annual bonus
• Equity participation
• Comprehensive benefits