Kymera Therapeutics is seeking a Scientist II or Senior Scientist to develop, optimize, and implement targeted proteomics analysis workflows to inform drug discovery and development decisions.
Requirements
- PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with a minimum of 2 years of experience in targeted, mass spectrometry–based proteomics in an industry or startup biotech setting;
- BS/MS with 8+ years of relevant experience;
- Broad expertise in targeted proteomics, including development and deployment of highly multiplexed and sensitive PRM or MRM stable isotope–labeled peptide assays using DDA and DIA data;
- Development of immunoaffinity enrichment methods to enhance MS sensitivity;
- Optimization of protein recovery from complex biological matrices (cells, tissues, plasma, biofluids) and various sample formulations (fresh, frozen, FFPE) across preclinical species;
- Operation, maintenance, and troubleshooting of nanoLC and Orbitrap MS instrumentation;
- Quantitative analysis and report generation using Skyline and related proteomics data tools;
- Demonstrated ability to independently analyze, interpret, and clearly communicate targeted proteomics data and conclusions to multidisciplinary teams;
- Proven success collaborating across functional areas and managing CRO relationships to deliver qualified assays that support drug discovery and clinical development;
- Strong organizational, problem-solving, and time-management skills with the ability to prioritize multiple projects to meet TPD drug discovery timelines;
- Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to both technical and non-technical audiences;
- Familiarity with regulatory filings (e.g., IND) and qualification of MS assays for clinical applications preferred;
- Working knowledge of automated sample processing, including immunoaffinity capture MS assays, is a plus.
Benefits
- Competitive compensation package
- Market-based, performance-driven pay
- Annual bonus
- Equity participation
- Comprehensive benefits
