Associate Principal Scientist, Upstream Process Development

The Biologics Process Research & Development organization is seeking a highly motivated and energetic individual to join our team as an Associate Principal Scientist. In this role, a successful candidate will work closely with a highly motivated team of Scientists and Engineers in the Upstream Process Development area and contribute to CMC development of our company's pipeline, playing an active role in the design, development, and optimization of cell culture processes and the transfer of processes to clinical and commercial manufacturing sites.

Requirements

• Ph.D. with 4+ years' experience or Master's with 8+ years' experience in chemical engineering, Bioengineering, Biological Engineering, or a related field
• Technical background and hands-on experience with mammalian cell culture and fed-batch processes to produce recombinant proteins
• Scientific understanding and working knowledge of CHO cell biology, metabolism, cell culture media and engineering principles for large scale recombinant protein production systems
• Working knowledge of statistical methods (design of experiment, multivariate data analysis) and tools (SIMCA, JMP, etc.)
• Understanding of cell culture bioreactors including microbioreactors, bench-scale and pilot-scale bioreactors, and bioreactor scale-up principles from laboratory to large scale
• Proven track record of accomplishments in upstream process and technology development with a strong scientific publication and presentation track record
• Ability to direct the planning, execution, analysis, and documentation of all stages of cell culture process development
• Plan, execute, analyze, and communicate complex and critical data in a highly organized manner
• Excellent verbal, written communication, and interpersonal skills
• Ability to work effectively in cross-functional and matrixed team environment; collaborate with both internal and external partners including vendors
• Demonstrated ability for taking initiative, creativity, and innovation in problem solving
• Productivity and efficiency working in the laboratory
• Ability to deliver complex objective under aggressive timelines
• Cell Line Development, Detail-Oriented, Downstream Process Development, Drug Delivery Technology, Drug Development, Expression Vectors, Interpersonal Relationships, Leading Project Teams, Molecular Biology, Pharmaceutical Formulations, Pharmaceutical Process Development, Physical Characterization, Stable Cell Lines, Strategic Planning

Benefits

• medical
• dental
• vision healthcare
• retirement benefits
• 401(k)
• paid holidays
• vacation
• compassionate and sick days