Senior Principal AI/ML Cheminformatics Scientist

As the world’s leading pharmaceutical company, Pfizer is in the unique position of having some of the largest and most complex chemical and biological data sets available anywhere. The Senior Principal AI/ML Cheminformatics Scientist will apply data-driven approaches to drug discovery-focused chemical and biological problems, apply and develop AI/ML models for molecular property prediction, and analyze and optimize hit to lead and lead optimization strategies from our proprietary knowledge base.

Requirements

• Drive scientific and technical advancement in PDM’s AI and cheminformatics capabilities by developing and delivering robust, validated workflows and algorithms that directly support drug discovery.
• Design, build, and deploy innovative cheminformatics and AI workflows for small molecule discovery, with clear deliverables including prioritized compound lists, well-defined chemical libraries, and actionable structure-activity relationship analyses.
• Collaborate closely with medicinal chemists, biologists, and data scientists to integrate computational approaches into experimental and analytical workflows.
• Continuously monitor and evaluate emerging advances in AI, cheminformatics, and computational drug discovery, proactively leading the adoption of promising new methodologies.
• Collaborate with cross-functional teams—including medicinal chemists, biologists, and data scientists—to integrate computational solutions into drug discovery workflows.
• Develop novel algorithms and analytical strategies tailored to Pfizer’s proprietary datasets and key scientific questions, with measurable outcomes such as validated models, software tools, and contributions to scientific literature or patent filings.

Benefits

• 401(k) plan with Pfizer Matching Contributions
• Paid vacation
• Holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage