Principal Scientist, Analytical Development, Oligo and Small Molecule

The Principal Scientist, Analytical Development will play a critical role in advancing Praxis' clinical and commercial pipeline by translating analytical strategies from development into manufacturing across our virtual network of CMOs and external partners. This role is particularly focused on advancing oligonucleotide-based therapeutics, while also supporting small molecule programs across the portfolio.

Requirements

• Serve as Analytical Lead across CMC programs, with primary responsibility for oligonucleotide analytical development activities and support for small molecule programs
• Lead analytical method development, qualification, validation, transfer, and GMP testing activities across internal teams and external partners
• Design and implement phase-appropriate analytical control strategies, specifications, and stability programs for oligonucleotide and small molecule drug substances and drug products
• Direct and manage CRO/CMO analytical partners to ensure high-quality execution, strong communication, and continuous operational improvement
• Contribute strategic and technical expertise to support regulatory filings, commercialization readiness, and ongoing product lifecycle management

Benefits

• 99% of the premium paid for medical, dental and vision plans
• Company-paid life insurance, AD&D, disability benefits, and voluntary plans
• 401(k) matching up to 6%
• Long-term stock incentives and ESPP
• Discretionary quarterly bonus
• Extremely flexible wellness benefit
• Generous PTO
• Paid holidays and company-wide shutdowns