Principal Scientist, Cancer Pharmacology, Translational Research

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. As a Principal Scientist, you will join the Cancer Pharmacology team within the Translational Research group to lead RAS(ON) inhibitor programs, drive in vivo efficacy and PK/PD studies, and contribute to regulatory submissions.

Requirements

• Ph.D. in Pharmacology or Cancer Biology, or a related scientific discipline with direct relevance to oncology drug development.
• 5+ years of relevant industry experience in oncology drug discovery and development.
• Demonstrated scientific leadership, strategic thinking, and problem-solving skills in advancing oncology drug discovery programs.
• Deep expertise in tumor biology, RAS signaling pathways, and translational oncology pharmacology.
• Extensive hands-on experience in the design, analysis, and interpretation of in vivo oncology studies and disease models.
• Strong understanding of translational PK/PD concepts and integration of efficacy, biomarker, and pharmacokinetic data to support translational hypotheses.
• Working knowledge of modeling approaches, including PBPK, QSP, and semi-mechanistic PK/PD frameworks.
• Proven track record of leading, mentoring, and developing scientific talent within collaborative, matrixed research environments.
• Excellent written and verbal communication skills with the ability to effectively communicate complex scientific concepts to both specialist and non-specialist audiences.
• Demonstrated track record of scientific innovation, productivity, and collaboration in a dynamic and fast-paced drug discovery environment.

Benefits

• Competitive cash compensation
• Robust equity awards
• Strong benefits
• Significant learning and development opportunities