Senior Director, Clinical Pharmacology

Centessa Pharmaceuticals plc is seeking an experienced Senior Director, Clinical Pharmacology to provide scientific and strategic leadership for clinical pharmacology across a diverse pipeline. The role requires expertise in PK, PD, PK/PD integration, exposure–response analyses, and drug–drug interaction assessment, with experience in developing and executing clinical pharmacology strategies for early‐ through late‐stage programs. The successful candidate will have a strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development, with excellent communication, collaboration, and leadership skills.

Requirements

• PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline
• 8–12+ years of experience in clinical pharmacology within biopharma, with demonstrated impact in clinical drug development
• Extensive experience developing and executing clinical pharmacology strategies for early‐ through late‐stage programs, including registrational support
• Strong expertise in PK, PD, PK/PD integration, exposure–response analyses, and drug–drug interaction assessment
• Demonstrated experience applying quantitative clinical pharmacology approaches (e.g., population PK, mechanistic PK/PD modeling) to inform CNS dose selection and optimization
• Proficiency with clinical pharmacology tools and platforms such as NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent
• Experience authoring and delivering clinical pharmacology components of regulatory submissions (e.g., INDs, CTAs, NDAs) and interacting with global health authorities
• Strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development
• Excellent communication, collaboration, and leadership skills with the ability to operate effectively in a fast‐paced, matrixed environment

Benefits

• 401(k) plan
• Company-sponsored medical, dental, vision, and life insurance
• Generous paid time off
• Health and wellness program