Senior Director, Toxicology (CNS Specialist)

Centessa Pharmaceuticals is seeking a Senior Director, Toxicology to provide scientific and technical leadership for nonclinical safety in CNS programs. The successful candidate will work independently to direct their own program work, provide day-to-day scientific guidance to entry-level toxicology staff, and collaborate closely with peers across nonclinical and development functions.

Requirements

• PhD in Toxicology, Pharmacology, Pathology, Neuroscience, DVM, or related discipline; board certification (e.g., DABT, ERT).
• 13+ years of pharmaceutical or biotechnology R&D experience with a strong track record in nonclinical and regulatory toxicology.
• Substantial experience supporting CNS / neuroscience drug development (required).
• Deep expertise supporting small molecule programs across discovery, IND-enabling, and early clinical development, with demonstrated experience advancing CNS-active candidates.
• Demonstrated experience serving as the toxicology lead on cross-functional drug development programs.
• Extensive experience authoring and reviewing nonclinical sections of global regulatory submissions (IND/CTA/IB/DSUR/NDA) and preparing written responses to health authority inquiries.

Benefits

• Comprehensive benefits package
• 401(k) plan
• Company-sponsored medical, dental, vision, and life insurance
• Generous paid time off
• Health and wellness program