Associate Scientist, in vitro Pharmacology and Assay Development

Metaphore is seeking a detail-oriented Associate Scientist to support in vitro pharmacology and assay development efforts within the Biology team. The role will focus on designing, developing, optimizing, and executing cell-based and biochemical assays to support discovery and preclinical programs.

Requirements

• Design, develop, optimize, and execute in vitro and ex vivo assays to support discovery and preclinical programs
• Perform medium-throughput ligand-binding and cell-based assays to characterize biological activity and support hit identification and lead optimization
• Develop and implement assays to evaluate pharmacokinetic (PK) and pharmacodynamic (PD) readouts from in vivo samples
• Generate custom engineered mammalian cell lines, culture and maintain primary cells, and apply these systems to biologically relevant assay development
• Analyze, interpret, and clearly communicate experimental data to cross-functional teams to inform program decisions
• Troubleshoot experimental challenges and independently drive assay improvements to ensure robustness, reproducibility, and scalability
• Collaborate closely with multidisciplinary teams including Discovery, Protein Sciences and Computational Biology to advance program objectives
• Contribute to the design and sourcing of critical reagents as needed
• Coordinate with external vendors and CROs to support assay execution and sample analysis
• Maintain accurate and timely documentation of experimental work in electronic lab notebooks and contribute to reports and presentations
• Contribute to a collaborative team environment, including sharing technical expertise and mentoring junior team members where appropriate

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits