General Proximity is a seed-stage startup developing the next generation of induced proximity medicines. We are seeking a first-rate computational chemist to help us pioneer this uncharted frontier of drug discovery. The role will drive small-molecule drug discovery programs by providing strategic and practical modeling support, implementing modern computational workflows, and building the cheminformatics and AI-enabled infrastructure needed to empower medicinal chemists and project teams.
Requirements
- PhD in Computational Chemistry, Medicinal Chemistry, Chemical Physics, Biophysics, Cheminformatics, Physical Organic Chemistry, or a related discipline
- A minimum of 15 years of relevant experience in pharma, biotech, or a drug discovery-focused research environment
- Demonstrated track record of using computational chemistry to impact small-molecule drug discovery programs
- Deep expertise in structure-based drug design, ligand-based design, docking, molecular dynamics, virtual screening, QSAR, FEP/free-energy methods, pharmacophore modeling, and multi-parameter optimization
- Strong working knowledge of medicinal chemistry principles, SAR interpretation, physicochemical property optimization, ADME/PK concepts, and developability considerations
- Practical experience with cheminformatics platforms, chemical databases, chemical data curation, compound registration systems, and project-facing visualization tools
- Experience with AI/ML applications in molecular design, including predictive modeling, generative chemistry, active learning, or AI-enabled compound prioritization
- Strong programming or scripting ability, preferably Python, with experience using cheminformatics toolkits such as RDKit and modern data science workflows
- Ability to communicate complex computational concepts clearly to medicinal chemists, biologists, executives, and non-specialist stakeholders
- Demonstrated ability to lead cross-functional teams, mentor scientists, and influence project strategy without relying solely on formal authority
Benefits
- Strong equity incentives
- Top tier medical, dental, and vision coverage + One Medical membership
- 401(k) retirement plans
- Education and health/fitness incentive programs
- Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days
- Reading budget!
