Scientist, Medicinal Chemistry

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.

Requirements

• PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Able to work fluently at the interface of chemistry and biology.
• Top-notch written and oral communication skills.
• Strong experience in Design, synthesis, and optimization of induced proximity medicines (e.g. PROTACs or other IPMs)
• Hit-to-lead and lead optimization campaigns
• Multi-step organic synthesis, with a proven ability to design and execute complex synthetic routes toward drug-like small molecules
• Medicinal chemistry optimization: SAR, PK/PD, and strong working knowledge of DMPK principles
• Chemical biology techniques including mammalian cell culture, cell-based assays (e.g., cytotoxicity, transfections, stable cell line generation, co-IP), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen); computational chemistry experience also welcomed

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage + One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats
• Reading budget