Scientist II/Senior Scientist, Medicinal Chemistry
General ProximitySan Francisco, California, United States
Posted May 15, 2026
Full Time
About the Company
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve the challenge of developing molecules capable of modulating difficult or 'undruggable' targets.
Job Description
General Proximity is a seed-stage startup developing induced proximity medicines (IPMs) to overcome therapeutic challenges. We are seeking a medicinal chemist to help pioneer this uncharted frontier of drug discovery.
Requirements
- Design and advance medicinal chemistry strategies for next-generation induced proximity medicines
- Lead compound design and SAR campaigns from hit finding through hit-to-lead and lead optimization
- Manage external chemistry CROs, including compound design prioritization, synthetic execution, timelines, and data review
- Direct external DMPK studies and interpret in vitro and in vivo data to guide compound progression
- Partner closely with Biology and Platform teams to design screening strategies and support compound evaluation in biochemical, biophysical, and cellular assays
- Contribute to mechanistic studies that strengthen understanding of lead molecules and inform program direction
- Support intellectual property strategy through invention generation and contributions to patent filings
- Help evaluate and expand opportunities into new disease areas and therapeutic applications
Benefits
- Strong equity incentives
- Top tier medical, dental, and vision coverage
- 401(k) retirement plans
- Education and health/fitness incentive programs
- Meditation retreats
- Reading budget
