Head of DMPK
General ProximitySan Francisco, California, United States
Posted May 15, 2026
Full Time
About the Company
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve the challenge of developing molecules capable of modulating difficult or 'undruggable' targets.
Job Description
We are seeking a Head of DMPK to lead and shape our drug metabolism and pharmacokinetics function. This is a high-impact leadership role in which you will own the DMPK strategy across our small molecule portfolio, build and mentor a growing team, and serve as the primary DMPK voice in cross-functional and external settings.
Requirements
- PhD in Pharmacokinetics, Pharmaceutical sciences, or a related discipline
- A minimum of 10 years of industry experience in DMPK, preferably in large pharma, spanning drug discovery and development, with a track record of advancing small molecule programs
- Demonstrated leadership experience, including managing scientists, building teams, and influencing cross-functional strategy
- Deep expertise in in vitro ADME and in vivo PK, with the ability to translate data into actionable drug discovery insights at a program level
- Expert-level proficiency in PK data analysis (Phoenix WinNonlin or equivalent) and PBPK/PK-PD modeling platforms (Simcyp, GastroPlus, or equivalent)
Benefits
- Strong equity incentives
- Top tier medical, dental, and vision coverage + One Medical membership
- 401(k) retirement plans
- Education and health/fitness incentive programs
- Meditation retreats
- Reading budget
