Director, Oligo Team Lead

Manifold Bio is a dynamic biotech company building a pipeline of targeted biologics using a novel in vivo-centric discovery approach. We are seeking an experienced drug development leader to guide strategy and execution of our shuttled oligonucleotide therapeutics programs.

Requirements

• PhD in a relevant field (chemistry, biochemistry, nucleic acid chemistry/biology, biophysics, molecular biology, pharmacology or related discipline)
• Minimum of 10 years post-PhD experience, including experience in industry drug-discovery programs
• Diverse experience with multiple oligonucleotide modalities (ASOs, siRNAs, aptamers, mRNA), different backbone chemistries/modifications
• Knowledge of proven and emerging technologies for delivering oligo medicines to cellular targets (LNPs, passive or active targeting moieties, etc.)
• Experience progressing oligonucleotide therapies from early discovery through IND-enabling preclinical activities / early clinical development
• Demonstrated leadership of effective specialized and cross-functional scientific teams
• Demonstrated ability to mentor junior scientists
• Excellent written and verbal communication skills

Benefits

• Competitive salary
• Benefits package
• Opportunity to work on innovative projects
• Collaborative and dynamic work environment