Senior DMPK Director

The Senior DMPK Director has strong scientific, technical and leadership skills to develop and implement DMPK and modeling & simulation strategies to advance drug candidates from discovery to development stage and build comprehensive DMPK packages to enable successful drug registration.

Requirements

• PhD degree in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or other relevant field
• Minimum 12 years of relevant experience in DMPK in the pharmaceutical industry
• Expert knowledge of in vitro and in vivo ADME studies
• Strong experience of managing external DMPK work at CROs
• Extensive experience in identifying clinical candidates through balancing ADME, pharmacology and toxicology properties and progressing molecules into clinical trials
• Solid experience in utilization of physiologically-based and empirical modeling and simulations techniques to characterize drug-drug interactions and biopharmaceutics liabilities
• Experience with submission of IND/NDA/BLA and global marketing applications
• Experience with antibody drug conjugates is a plus
• Extensive scientific and technical knowledge around drug metabolism and drug transporters, including enzymology and enzyme kinetics and in vitro to in vivo extrapolation
• Demonstration of independent thought/creativity in science and drug discovery
• In-depth knowledge of current practices and issues in DMPK (including regulatory requirements), PKPD and translational sciences
• Keen desire to grow and develop the careers of team members
• Demonstrates strong leadership; and has the ability to influence and make decisions
• Excellent collaborative verbal and written communication skills
• Able to work well with multi-disciplinary teams
• Works on problems of diverse scope where analysis and review of data requires evaluation of identifiable factors
• Works on ADME complex issues where analysis of situations or data requires an in-depth evaluation of variable factors

Benefits

• 401k plan with generous company contributions
• Group medical, dental and vision coverage
• Life and disability insurance
• Flexible spending accounts
• Discretionary annual bonus program
• Sales-based incentive plan
• Opportunity to purchase company stock
• Long-term incentives
• 15 accrued vacation days in their first year
• 17 paid holidays including a company-wide winter shutdown in December
• Up to 10 sick days throughout the calendar year