GSK is seeking a highly motivated Scientist to join the growing Oligo Discovery Biology group. In this new role, you will be pivotal in driving the team's sequencing strategy, responsible for developing and executing next-generation sequencing (NGS) workflows to measure the efficacy and specificity of GSK's diverse oligonucleotide modalities (ASOs, siRNAs, SSOs & RNA editors). Your work will be critical in supporting the platform's high-throughput screening efforts and advancing our therapeutic programs.
Requirements
- Design, optimize, and execute next-generation sequencing (NGS) assays (e.g., RNA-seq, Amp-Seq) to characterize oligonucleotide activity, including on-target efficacy and transcriptome-wide off-target effects.
- Independently manage the wet-lab workflow from nucleic acid extraction (RNA/DNA) through to NGS library preparation and quality control.
- Perform primary analysis of sequencing data for quality assessment and collaborate with bioinformatics colleagues on the interpretation of complex datasets.
- Analyze and interpret experimental results, clearly communicating findings and their impact to the project team and stakeholders.
- Collaborate effectively with team members and cross-functional partners in biology, chemistry, and bioinformatics to advance platform capabilities and portfolio projects.
- Maintain meticulous records of experiments, sample metadata, and results in an electronic laboratory notebook (ELN).
Benefits
- Annual bonus
- Eligibility to participate in share-based long-term incentive program
- Health care and other insurance benefits
- Retirement benefits
- Paid holidays
- Vacation
- Paid caregiver/parental and medical leave
