Sr. Director, Biotherapeutics

Manifold Bio is seeking a Senior Director of Biotherapeutics to guide the discovery, characterization, and production of shuttled therapeutics. The ideal candidate will have extensive experience in biotherapeutics, protein engineering, and team leadership.

Requirements

• Extensive experience in biotherapeutics across a range of protein modalities
• Proven track record engineering antibodies for clinical development
• Expertise with novel modalities and complex formats, including ADCs, tissue-targeted therapeutics, and bispecific antibodies
• Deep knowledge of state-of-the-art protein engineering approaches, including display technologies
• Experience with protein expression systems, purification methods, and characterization including developability assays
• Prior experience liaising with CDMOs, particularly through IND
• Understanding of assay development and typical strategies to select development candidates
• Extensive experience leading both functional teams and matrix project teams
• Strong mentorship and management skills with demonstrated ability to develop team members
• Proven ability to balance diving into details while avoiding micromanagement
• Track record of efficient execution and resource/budget planning
• Demonstrated ownership and accountability in previous roles
• Experience at smaller companies where leaders must directly drive execution and 'roll up their sleeves'
• Ability to clearly articulate core competencies and work effectively with external consultants
• Easy to work with with a collaborative mindset
• Brings joy and energy to work and inspires those around them
• Humility and team-first approach; servant leadership style
• Comfortable in fast-moving, agile organizations